Time trends towards earlier puberty in boys and girls with type 1 diabetes: Insights from the German Diabetes Prospective Follow‐up (DPV) registry, 2000 to 2021-Reference-Cited by-同舟云学术

Time trends towards earlier puberty in boys and girls with type 1 diabetes: Insights from the German Diabetes Prospective Follow‐up (DPV) registry, 2000 to 2021

Published:2023-10-12 Issue:1 Volume:26 Page:293-300
ISSN:1462-8902
Container-title:Diabetes, Obesity and Metabolism
language:en
Short-container-title:Diabetes Obesity Metabolism

Author:

Gohlke Bettina¹,Reschke Felix²^ORCID,Lanzinger Stefanie³⁴^ORCID,Boettcher Claudia⁵,Gemulla Gitta⁶,Thiele‐Schmitz Susanne⁷,Dunstheimer Désirée⁸,van den Boom Louise⁹,Woelfle Joachim¹⁰,Holl Reinhard W.³⁴

Affiliation:

1. Pediatric Endocrinology and Diabetology Division, Children's Hospital University of Bonn Bonn Germany

2. Centre for Diabetes and Endocrinology Children's Hospital Auf der Bult Hannover Germany

3. Institute of Epidemiology and Medical Biometry, ZIBMT University of Ulm Ulm Germany

4. German Center for Diabetes Research (DZD) Munich‐Neuherberg Munich Germany

5. Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Bern University Hospital, University of Bern, Switzerland; Department of Biomedical Research University of Bern Bern Switzerland

6. Pediatric Endocrinology University Children's Hospital Carl Gustav Carus, Technical University of Dresden Dresden Germany

7. Pediatric Endocrinology and Diabetology, Children's Hospital St. Vincenz Paderborn Germany

8. Department of Pediatric Endocrinology and Diabetology University Hospital Augsburg Augsburg Germany

9. Division of Pediatrics/Pediatric Diabetology DRK Hospital Kirchen Germany

10. Department of Pediatrics and Adolescent Medicine University Hospital Erlangen Erlangen Germany

Abstract

AbstractAimTo examine the time trends and factors associated with the onset of puberty in children with type 1 diabetes (T1D) using data from the German Diabetes Prospective Follow‐up (Diabetes‐Patienten‐Verlaufsdokumentation [DPV]) registry.MethodsA total of 13 127 children with T1D, aged 6 to 18 years, were included in the analysis. Regression analysis was performed to investigate the relationship between diabetes duration, body mass index (BMI) standard deviation score (SDS), glycated haemoglobin (HbA1c) level, migration background, and the onset of puberty, stratified by sex.ResultsOur findings revealed a significant trend towards earlier puberty in both girls and boys with T1D over the observed period (2000 to 2021). Puberty onset in girls (thelarche Tanner stage B2) decreased from 11.48 (11.35‐11.65) years in 2000 to 10.93 (10.79‐11.08) years in 2021 and gonadarche (Tanner stage G2/testicular volume >3 mL) decreased from 12.62 (12.42‐12.82) years in 2000 to 11.98 (11.79‐12.16) years in 2021 in boys (both P < 0.001). Longer diabetes duration, higher BMI SDS, and lower HbA1c level were associated with earlier puberty in both sexes (P < 0.001).ConclusionsOur study highlights earlier puberty in children with T1D, influenced by BMI SDS, HbA1c level, and migration background. This has important implications for diabetes management and supporting healthy development. Further research is needed to understand the underlying mechanisms and develop potential interventions for this vulnerable population.

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

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