Hypermobility spectrum disorders and active migraine in Israeli adolescents: A nationwide study

Author:

Zloof Yair123,Simchoni Maya4,Derazne Estela5,Tsur Avishai M.1346,Tzur Dorit1,Braun Maya1,Amarilyo Gil57,Shlaifer Amir14,Honig Asaf8,Braun‐Moscovici Yolanda910

Affiliation:

1. Israel Defense Forces Medical Corps Ramat Gan Israel

2. Schneider Children's Medical Center of Israel Petach Tikva Israel

3. Department of Preventive Medicine and Epidemiology, School of Public Health, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

4. Department of Military Medicine Hebrew University Jerusalem Israel

5. Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

6. Department of Medicine, Sheba Medical Center Tel Hashomer Ramat Gan Israel

7. Pediatric Rheumatology Unit Schneider Children's Medical Center of Israel Petach Tikva Israel

8. Department of Neurology Hadassah‐Hebrew University Medical Center Jerusalem Israel

9. B Shine Rheumatology Institute Rambam Health Care Campus Haifa Israel

10. Rappaport Faculty of Medicine Technion Haifa Israel

Abstract

AbstractObjectiveTo assess the association between hypermobility spectrum disorders/hypermobile type Ehlers Danlos Syndrome (HSD/hEDS) and migraine in a national sample of adolescents in Israel.BackgroundThe association between HSD/hEDS and migraine is unclear, even more so in pediatric populations.MethodsThis population‐based, cross‐sectional study included 1,627,345 Israeli adolescents (945,519/1,626,407 [58%] males; mean age 17 ± 0.5 years) who were medically assessed before mandatory military service during 1998–2020. Diagnoses of migraine with at least one attack per month (active migraine) and HSD/hEDS were confirmed by certified specialists. The prevalences of active migraine in adolescents with and without HSD/hEDS were computed and the association between HSD/hEDS and active migraine was examined.ResultsActive migraine was significantly more prevalent in adolescents with HSD/hEDS (307/4686 [6.5%]) compared to those without HSD/hEDS (51,931/1,621,721 [3.2%]) (OR = 2.16, 95% CI 1.90–2.45). The association between HSD/hEDS and active migraine persisted in a multivariable analysis (OR = 2.08, 95% CI 1.85–2.34) and in several sensitivity analyses.ConclusionsWe found a significant association between HSD/hEDS and active migraine in both male and female adolescents. Clinical awareness of the association can promote early diagnosis and treatment of migraine. Further research is required to identify appropriate pharmacologic and nonpharmacologic migraine treatment strategies for individuals with HSD/hEDS.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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