Affiliation:
1. Department of Dermatology First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China
2. Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education Hefei Anhui 230022 China
3. Inflammation and Immune‐Mediated Diseases Laboratory of Anhui Province Hefei Anhui 230022 China
4. The Fifth Clinical Medical College of Anhui Medical University Anhui Medical University Hefei 230032 China
5. Department of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine Anhui Medical University Hefei 230032 China
Abstract
AbstractBackgroundHemoporfin‐mediated photodynamic therapy (HMME‐PDT) is currently considered one of the most promising therapies for port‐wine stain (PWS). However, the efficacy of this is very variable and needs further studies.MethodsA total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME‐PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.ResultsThe efficacy of HMME‐PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above‐mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.ConclusionsOur studies demonstrated that HMME‐PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin‐PDT, while multiple HMME‐PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.
Subject
Dermatology,Radiology, Nuclear Medicine and imaging,Immunology,General Medicine,Immunology and Allergy
Cited by
1 articles.
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