Pharmacokinetics and pharmacodynamics of oral and intravenous metoprolol tartrate in clinically healthy horses

Author:

Luethy Daniela12ORCID,Robinson Mary A.13,Stefanovski Darko1,Haughan Joanne1,Torcivia Catherine1,Kowalski Alycia1,Ford Matthew1,You Youwen3,Missanelli Jaclyn3,Slack Joann1

Affiliation:

1. Department of Clinical Studies‐New Bolton Center School of Veterinary Medicine University of Pennsylvania Kennett Square Pennsylvania USA

2. Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA

3. Pennsylvania Equine Toxicology and Research Lab School of Veterinary Medicine University of Pennsylvania West Chester Pennsylvania USA

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference37 articles.

1. A randomized controlled phase IIb trial of beta(1)‐receptor blockade for chronic degenerative mitral regurgitation;Ahmed M. I.;Journal of the American College of Cardiology,2012

2. Pharmacokinetics of propranolol and its metabolites in horses after intravenous or oral administration;Aramaki S.;Biological &/and Pharmaceutical Bulletin,2000

3. Pharmacodynamics of beta‐blockers in heart failure: Lessons from the carvedilol or metoprolol European trial;Bauman J. L.;Journal of Cardiovascular Pharmacology and Therapeutics,2004

4. Combined pharmacokinetic and pharmacodynamic studies of metoprolol in the cat and the dog;Borg K. O.;Acta Pharmacologica Et Toxicologica,1975

5. Metabolism of metoprolol‐(3‐h) in man, the dog and the rat;Borg K. O.;Acta Pharmacologica Et Toxicologica,1975

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