Clonal haematopoiesis: A common progenitor for cytotoxic peripheral T‐cell lymphoma and angioimmunoblastic T‐cell lymphoma

Abstract

SummaryRecent studies have shown that follicular helper T‐cell lymphoma of angioimmunoblastic type (AITL), the most common nodal peripheral T‐cell lymphoma (PTCL), frequently arises in a background of clonal haematopoiesis (CH), a preneoplastic condition affecting up to 40% of elderly individuals. Data on a potential CH association are limited for other PTCL. We report a unique patient who sequentially developed both cytotoxic PTCL, not otherwise specified and AITL with distinct T‐cell receptor rearrangements but shared somatic mutations originating from the same CH clone, thus providing convincing evidence that CH can give rise to T‐cell neoplasms of different lineage.