Orodental health status of patients with inborn errors of immunity

Author:

Chaiboonyarak Thitaya12ORCID,Chantarangsu Soranun3,Gavila Patcharaporn124,Lao‐Araya Mongkol5,Suratannon Narissara67,Porntaveetus Thantrira12ORCID

Affiliation:

1. Center of Excellence in Genomics and Precision Dentistry, Department of Physiology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand

2. Geriatric Dentistry and Special Patients Care International Program, Faculty of Dentistry Chulalongkorn University Bangkok Thailand

3. Department of Oral Pathology, Faculty of Dentistry Chulalongkorn University Bangkok Thailand

4. Department of Health, Intercountry Center for Oral Health Ministry of Public Health Chiang Mai Thailand

5. Division of Allergy and Clinical Immunology, Department of Pediatrics, Faculty of Medicine Chiang Mai University Chiang Mai Thailand

6. Center of Excellence for Allergy and Clinical Immunology, Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Faculty of Medicine Chulalongkorn University Bangkok Thailand

7. The King Chulalongkorn Memorial Hospital the Thai Red Cross Society Bangkok Thailand

Abstract

AbstractBackgroundVarious orodental problems affect patients with inborn errors of immunity (IEI), but there are limited studies on these issues.AimTo study orodental status and its confounding factors in patients with IEI.DesignCaries, enamel defects, gingival, and soft tissue conditions were examined. Data on patient characteristics, dental hygiene habits, dental attendance, and household income were collected. Statistical analysis and logistic regression were performed.ResultsForty‐five participants with a mean age of 9.20 ± 6.41 years were included. Almost all participants had gingivitis (42 of 45; 93.3%), whereas a small number had periodontitis (five of 45; 11.1%). Calculus was found in 33 (73.3%) and caries in 30 (66.7%). Mucosal ulcers, enamel defects, and candidiasis were observed in 23 of 45 (51.1%), 16 of 43 (37.2%), and six of 43 (14.0%), respectively. Chances of having caries, moderate‐to‐severe gingivitis, periodontitis, calculus, and ulcers increased with age. Taking antibiotics in the last two months increased the risk of caries by five times. Lower income increased the risk of calculus deposit by nine times.ConclusionGingivitis, calculus, caries, and mucosal ulcers were the most common orodental findings in patients with IEI. Antibiotics increased the risk of caries, and low‐income children had higher calculus accumulation.

Funder

Chulalongkorn University

Faculty of Dentistry, Chulalongkorn University

Health Systems Research Institute

National Research Council of Thailand

Publisher

Wiley

Subject

General Dentistry

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