TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects

Author:

Busserolles Jérôme12ORCID,Ben Soussia Ismail3,Pouchol Laetitia12,Marie Nicolas4,Meleine Mathieu12,Devilliers Maïly12,Judon Céline12,Schopp Julien12,Clémenceau Loïc4,Poupon Laura12,Chapuy Eric12,Richard Serge5,Noble Florence4,Lesage Florian3,Ducki Sylvie6,Eschalier Alain12,Lolignier Stéphane12ORCID

Affiliation:

1. Université Clermont Auvergne, Inserm, Neuro‐Dol Clermont‐Ferrand F‐63000 France

2. Faculté de Médecine Institut Analgesia Clermont‐Ferrand France

3. Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Labex ICST Université Côte d'Azur, INSERM Valbonne France

4. Neuroplasticité et thérapie des addictions Université Paris Descartes, CNRS, Inserm Paris France

5. Centre de Recherches Biologiques CERB Baugy France

6. ICCF, SIGMA Clermont Université Clermont Auvergne, CNRS Clermont‐Ferrand France

Funder

European Regional Development Fund

Conseil Régional d'Auvergne

Fondation Fyssen

Publisher

Wiley

Subject

Pharmacology

Reference60 articles.

1. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

2. TREK-1, a K+ channel involved in polymodal pain perception

3. A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

4. Comparison of behavioral effects after single and repeated administrations of four benzodiazepines in three mice behavioral models;Bourin M.;Journal of Psychiatry & Neuroscience: JPN,1992

5. Quantitative assessment of tactile allodynia in the rat paw

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