Affiliation:
1. School of Stomatology Zunyi Medical University Zunyi China
2. Department of Orthodontics Affiliated Stomatological Hospital of Zunyi Medical University Zunyi China
3. Department of Otolaryngology. Longgang E.N.T Hospital & Shenzhen Key Laboratory of E.N.T Institute of E.N.T Shenzhen Shenzhen China
4. Special Key Laboratory of Oral Diseases Research, Higher Education Institution Zunyi China
Abstract
AbstractPeriodontitis is a prevalent oral disease caused by chronic inflammation of the periodontal tissues surrounding the teeth, which can lead to bone loss, tooth loosening, and even tooth loss. This inflammation has a negative impact on the osteogenic differentiation capacity of periodontal tissue‐derived cells. Non‐coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins but can regulate various physiological processes. In this review, we summarized the critical signaling pathways that ncRNAs modulate in osteogenic differentiation of periodontal tissue‐derived cells, such as the Wnt, BMP/Smad, NF‐κB, and PI3‐K/Akt/mTOR pathways. This comprehensive exploration of ncRNA‐mediated modulation offers fresh and promising insights for prospective approaches in the management of periodontitis and the advancement of periodontal regeneration therapies.
Funder
National Natural Science Foundation of China
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