Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats

Author:

Abdelgied Mohamed123,El-Gazzar Ahmed M.124,Alexander David B.1ORCID,Alexander William T.1,Numano Takamasa1,Iigou Masaaki1,Naiki-Ito Aya2,Takase Hirotsugu5,Abdou Khaled Abbas3,Hirose Akihiko6,Taquahashi Yuhji7,Kanno Jun8,Tsuda Hiroyuki1,Takahashi Satoru2

Affiliation:

1. Nanotoxicology Project; Nagoya City University; Nagoya Japan

2. Department of Experimental Pathology and Tumor Biology; Nagoya City University Graduate School of Medical Sciences; Nagoya Japan

3. Department of Forensic Medicine and Toxicology; Faculty of Veterinary Medicine; Beni Suef University; Beni-Suef Egypt

4. Department of Forensic Medicine and Toxicology; Faculty of Veterinary Medicine; Alexandria University; Alexandria Egypt

5. Core Laboratory; Nagoya City University Graduate School of Medical Sciences; Nagoya Japan

6. Division of Risk Assessment; National Institute of Health Sciences; Tokyo Japan

7. Division of Cellular and Molecular Toxicology; National Institute of Health Sciences; Tokyo Japan

8. Japan Industrial Safety and Health Association; Japan Bioassay Research Center; Kanagawa Japan

Funder

Ministry of Health, Labour and Welfare

Verband der Chemischen Industrie

Cultural Affairs and Missions Sector, Ministry of Higher Education

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference36 articles.

1. Clearance of inhaled potassium Octatitanate Whisker from rat lungs;Yamato;J Occup Health,2002

2. Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design;Donaldson;Nanomedicine (Lond),2011

3. A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples;Adachi;Ind Health,2001

4. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals;Stanton;J Natl Cancer Inst,1981

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