PDGFRA mRNA is overexpressed in oral cancer patients as compared to normal subjects with a significant trend of overexpression among tobacco users

Author:

Ong Hui Shan1,Gokavarapu Sandhya2,Tian Zhen3,Li Jiang3,Xu Qin4,Cao Wei1,Zhang Chen Ping1ORCID

Affiliation:

1. Department of Oral and Maxillofacial-Head & Neck Oncology; Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai China

2. Head & Neck Oncology Reconstructive Surgery; Department of Surgical Oncology; Krishna Institute of Medical Science; Hyderabad Telangana India

3. Department of Oral Pathology; Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai China

4. Shanghai Key Laboratory of Oral and Maxillofacial-Head & Neck Oncology and Shanghai Research Institute of Stomatology; Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai China

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Health Bureau Scientific Research Projects

Publisher

Wiley

Subject

Periodontics,Cancer Research,Otorhinolaryngology,Oral Surgery,Pathology and Forensic Medicine

Reference27 articles.

1. http://www.cancerindex.org/geneweb//PDGFRA.htm

2. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops;Hermanson;Can Res,1992

3. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse;Hellstrom;Development,1999

4. Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial;Reichardt;BMC Cancer,2016

5. Oncogene Fip1-likeL/PDGFRalpha as a target for imatinib in patients with hypereosinophilic syndrome and chronic eosinophilic leukemia. A novel look at pathogenesis and therapy;Helbig;Pol Arch Med Wewn,2005

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