Affiliation:
1. Post‐Graduate Program in Parasitology Universidade Federal de Pelotas (UFPel) Pelotas Brazil
2. Center for Technological Development – Biotechnology UFPel Pelotas Brazil
3. Post‐Graduate Program in Health Science Universidade Federal do Rio Grande (FURG) Rio Grande, Rio Grande do Sul Brazil
Abstract
SummaryIn this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL‐12 gene transcription had 40‐fold increase in S. boulardii supplemented uninfected mice and sevenfold increase in supplemented infected mice comparing with not supplemented group. Regarding IFNγ, similar results were observed, since probiotic supplementation induced approximately 43‐fold increase, but only in uninfected mice (P < 0·05). T. canis infection upregulated IL‐10 expression while S. boulardii downregulated it and no change was observed for IL‐4. Thus, based in these findings; we suggest that one possible mechanism responsible for S. boulardii protection effect against T. canis infection is by the modulation of cytokines expression, especially IL‐12.
Funder
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul for available resources
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Post-Graduate Program in Parasitology (UFPel)
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献