A Randomized Controlled Trial Comparing the Efficacy ofCyp3a5Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation

Author:

Shuker N.12,Bouamar R.2,van Schaik R. H. N.3,Clahsen-van Groningen M. C.4,Damman J.5,Baan C. C.1,van de Wetering J.1,Rowshani A. T.1,Weimar W.1,van Gelder T.12,Hesselink D. A.1

Affiliation:

1. Department of Internal Medicine; Erasmus Medical Centre; Rotterdam The Netherlands

2. Department of Hospital Pharmacy; Erasmus Medical Centre; Rotterdam The Netherlands

3. Department of Clinical Chemistry; Erasmus Medical Centre; Rotterdam The Netherlands

4. Department of Pathology; Erasmus Medical Centre; Rotterdam The Netherlands

5. Department of Pathology; Academic Medical Centre; Amsterdam The Netherlands

Funder

The Netherlands Organization for Scientific Research (NWO)

Nierstichting

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference35 articles.

1. OPTN/SRTR 2011 annual data report: Kidney;Matas;Am J Transplant,2013

2. Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation;Staatz;Clin Pharmacokinet,2004

3. Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus;Kamdem;Clin Chem,2005

4. Metabolism of the immunosuppressant tacrolimus in the small intestine: Cytochrome P450, drug interactions, and interindividual variability;Lampen;Drug Metab Dispos,1995

5. The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation;Hesselink;Clin Pharmacokinet,2014

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