Living donor liver transplantation: A multi‐disciplinary collaboration towards growth, consensus, and a change in culture

Author:

Liapakis AnnMarie1,Jesse Michelle T2,Pillai Anjana3,Bittermann Therese4,Dew Mary Amanda5ORCID,Emre Sukru6,Hunt Heather7,Kumar Vineeta8,Locke Jayme8,Mohammad Saeed9,Olthoff Kim10,Verna Elizabeth C.11,Lentine Krista L12,

Affiliation:

1. Yale School of Medicine and Yale New Haven Transplant Center New Haven Connecticut USA

2. Transplant Institute Henry Ford Health System Detroit Michigan USA

3. Department of Medicine University of Chicago Medicine Chicago Illinois USA

4. University of Pennsylvania Philadelphia Pennsylvania USA

5. University of Pittsburgh School of Medicine and Medical Center Pittsburgh Pennsylvania USA

6. Ege University School of Medicine Izmir Turkey

7. Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) Living Donor Committee Richmond Virginia USA

8. Department of Medicine, Division of Nephrology/Transplant University of Alabama at Birmingham Birmingham Alabama USA

9. Vanderbilt University Medical Center Nashville Tennessee USA

10. University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

11. Center for Liver Disease and Transplantation Columbia University New York USA

12. Saint Louis University Transplant Center St. Louis Missouri USA

Abstract

AbstractIntroductionLiving donor liver transplantation (LDLT) reduces liver transplant waitlist mortality and provides excellent long‐term outcomes for persons with end stage liver disease. Yet, utilization of LDLT has been limited in the United States (US).MethodsIn October 2021, the American Society of Transplantation held a consensus conference to identify important barriers to broader expansion of LDLT in the US, including data gaps, and make recommendations for impactful and feasible mitigation strategies to overcome these barriers. Domains addressed encompassed the entirety of the LDLT process. Representation from international centers and living donor kidney transplantation were included for their perspective/experience in addition to members across disciplines within the US liver transplantation community. A modified Delphi approach was employed as the consensus methodology.ResultsThe predominant theme permeating discussion and polling results centered on culture; the beliefs and behaviors of a group of people perpetuated over time.ConclusionsCreating a culture of support for LDLT in the US is key for expansion and includes engagement and education of stakeholders across the spectrum of the process of LDLT. A shift from awareness of LDLT to acknowledgement of benefit of LDLT is the primary goal. Propagation of the maxim "LDLT is the best option" is pivotal.

Publisher

Wiley

Subject

Transplantation

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