Patient harboring a novelPIK3CApoint mutation after acquired resistance to crizotinib in an adenocarcinoma withROS1rearrangement: A case report and literature review

Author:

Xu Chun-wei1ORCID,Wang Wen-xian2,Huang Rong-fang1,He Cheng1,Liao Xing-hui3,Zhu You-cai4,Du Kai-qi4,Zhuang Wu5,Chen Yan-ping1,Chen Gang1,Fang Mei-yu6

Affiliation:

1. Department of Pathology, Fujian Provincial Cancer Hospital; Fujian Medical University Cancer Hospital; Fuzhou China

2. Department of Chemotherapy; Zhejiang Cancer Hospital; Hangzhou China

3. Department of Tumor Molecular Laboratory; Zhejiang Rongjun Hospital; Jiaxing China

4. Department of Thoracic Disease Center; Zhejiang Rongjun Hospital; Jiaxing China

5. Department of Medical Thoracic Oncology, Fujian Provincial Cancer Hospital; Fujian Medical University Cancer Hospital; Fuzhou China

6. Department of Comprehensive Medical Oncology; Zhejiang Cancer Hospital; Hangzhou China

Funder

Medical Scientific Research Foundation of Zhejiang Province of China

National Clinical Key Specialty Construction Program (2013)

Science and Technology Planning Project of Zhejiang Province of China

Zhejiang Administration of Traditional Chinese Medicine Foundation

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine,Oncology,General Medicine

Reference24 articles.

1. Cancer statistics, 2017;Siegel;CA Cancer J Clin,2017

2. Cancer treatment and survivorship statistics, 2014;DeSantis;CA Cancer J Clin,2014

3. The pivotal role of pathology in the management of lung cancer;Davidson;J Thorac Dis,2013

4. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib;Lynch;N Engl J Med,2004

5. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy;Paez;Science,2004

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