S‐acylation: an orchestrator of the life cycle and function of membrane proteins

Author:

Mesquita Francisco S.1ORCID,Abrami Laurence1,Samurkas Arthur1,van der Goot F. Gisou1ORCID

Affiliation:

1. Global Health Institute, School of Life Sciences EPFL Lausanne Switzerland

Abstract

S‐acylation is a covalent post‐translational modification of proteins with fatty acids, achieved by enzymatic attachment via a labile thioester bond. This modification allows for dynamic control of protein properties and functions in association with cell membranes. This lipid modification regulates a substantial portion of the human proteome and plays an increasingly recognized role throughout the lifespan of affected proteins. Recent technical advancements have propelled the S‐acylation field into a ‘molecular era’, unveiling new insights into its mechanistic intricacies and far‐reaching implications. With a striking increase in the number of studies on this modification, new concepts are indeed emerging on the roles of S‐acylation in specific cell biology processes and features. After a brief overview of the enzymes involved in S‐acylation, this viewpoint focuses on the importance of S‐acylation in the homeostasis, function, and coordination of integral membrane proteins. In particular, we put forward the hypotheses that S‐acylation is a gatekeeper of membrane protein folding and turnover and a regulator of the formation and dynamics of membrane contact sites.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

National Center of Competence in Research Chemical Biology

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Mechanisms and functions of protein S-acylation;Nature Reviews Molecular Cell Biology;2024-02-14

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