Affiliation:
1. Department of Dermatology The Chaim Sheba Medical Center Ramat Gan Israel
2. Division of Gastroenterology Rabin Medical Center Petah Tikva Israel
3. Faculty of Medicine Tel Aviv University Tel Aviv Israel
4. School of Public Health University of Haifa Haifa Israel
5. Division of Dermatology Rabin Medical Center Petah Tikva Israel
Abstract
AbstractBackgroundAtopic dermatitis (AD) and inflammatory bowel disease (IBD) share genetic susceptibility loci with immune regulation functions. Atopic dermatitis was associated with IBD mostly in database studies.ObjectiveTo assess whether AD is associated with an increased prevalence of IBD in a tertiary dermatology clinic.MethodsA retrospective cross‐sectional analysis using medical records of adults with verified AD followed up at an AD clinic, compared with age‐ and sex‐matched (1:2) controls from the general dermatology clinic in the same hospital.ResultsOverall, 9/364 (2.47%) of patients with AD had verified IBD, compared with 7/725 (0.97%) of controls (p = 0.0512). In multivariable logistic regression adjusting for age, gender and smoking, the association became significant (adjusted OR = 3.89, 95% CI: 1.28–11.85). Stratified for AD severity, only moderate‐to‐severe AD was associated with IBD (p = 0.035), with an adjusted OR of 4.45 (95% CI: 1.43–13.90). Mild AD was not associated with IBD, but the study was not powered for this sub‐analysis. In the AD group, older age was associated with IBD (p = 0.0172).ConclusionThis study, in a robustly verified cohort of patients, supports an association between AD, especially the moderate‐to‐severe forms, and IBD. A multidisciplinary approach for patients with moderate‐to‐severe AD should extend to consider IBD.
Subject
Infectious Diseases,Dermatology