The effects of fucoidan‐rich polysaccharides extracted from Sargassum horneri on enhancing collagen‐related skin barrier function as a potential cosmetic product

Abstract

AbstractBackgroundSargassum horneri came ashore after flowing from the South China Sea to Jeju Island a few years ago. This caused a significant environmental impact on coastal areas where S. horneri has accumulated because of decomposition and the release of toxic substances, such as hydrogen sulfide.AimsIn this study, we evaluated a biological ingredient prepared from fucoidan‐rich S. horneri and demonstrated its antiwrinkle effects on ultraviolet B (UVB)‐induced fibroblast cells.Materials and MethodsFucoidan samples from S. horneri were prepared according to a previously published process with modifications. The compositional analysis of S. horneri fucoidan extract (SHFE) as well as its effects on antiaging were examined to determine its utility as a functional material.ResultsSHFE exhibited antioxidant properties using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging assay. Treatment of UVB‐induced fibroblasts with SHFE significantly increased the synthesis of procollagen compared with adenosine treatment and inhibited MMP‐1 and MMP‐3 expression. In a clinical study, SHFE lotion improved skin barrier effects in forearms and transepidermal water loss (TEWL) values were reduced after 3 weeks of use compared with a placebo.ConclusionSHFE has utility as an additive with functional antiaging effects for a range of cosmetic products as it restores skin hydration in the epidermal barrier.