Affiliation:
1. Student Research Committee Gonabad University of Medical Sciences Gonabad Iran
2. Department of Dermatology, Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran
3. Department of Biology, Tehran Medical Branch Islamic Azad University Tehran Iran
4. Medical Technical College Al‐Farahidi University Baghdad Iraq
5. Department of Hematology, Faculty of Medical Sciences Tarbiat Modares University Tehran Iran
Abstract
AbstractBackgrounds and ObjectiveDuring fat transplantation, adipose tissue is removed from the body and injected into different areas under the skin. The goal of this review article is to look into the efficacy and applicability of fat transplantation in regenerative medicine and rejuvenation, including Nanofat, Microfat, and Millifat.MethodsAs a search strategy and study selection, we searched the PubMed and Medline databases until 2023 using related keywords (e.g., Nanofat, Microfat and Millifat, Regenerative Medicine, and Rejuvenation).ResultsAutologous fat transplantation has no risk of an allergic reaction or rejection of the transplant by the individual. Autologous adipose tissue is considered an ideal filler for facial rejuvenation and is suggested as the most biocompatible and non‐immunogenic skin filler. Adipose tissue transplant may have semi‐permanent to permanent effects. According to recent reports, adipose tissues possess a high percentage of mature stem cells. The effect of regenerating adipose tissue and its intrinsic cells can be described as an obvious process. Variations in the sizes of adipose tissues can result in different results depending on the surgical site. Based on topographic assessment, graft fats are assigned depending on the anatomical locations and the size such as Millifat (2–2.5 mm), Microfat (1 mm), and Nanofat (500 μm or less).ConclusionSome characteristics of fat tissue increase its effectiveness, such as increasing stem cells, growth factors, cytokines, and compounds effective in repair, regeneration, and rejuvenation.