Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study

Author:

Shuffrey Lauren C.1ORCID,Morales Santiago2,Jacobson Melanie H.3,Bosquet Enlow Michelle45,Ghassabian Akhgar6,Margolis Amy E.1ORCID,Lucchini Maristella1,Carroll Kecia N.7,Crum Rosa M.8,Dabelea Dana9,Deutsch Arielle10,Fifer William P.111,Goldson Brandon7,Hockett Christine W.1012,Mason W. Alex13,Jacobson Lisette T.14,O'Connor Thomas G.15ORCID,Pini Nicolò1,Rayport Yael1,Sania Ayesha1,Trasande Leonardo16,Wright Rosalind J.7,Lee Seonjoo17,Monk Catherine11819,

Affiliation:

1. Department of Psychiatry Columbia University Vagelos College of Physicians and Surgeons New York New York USA

2. Department of Psychology University of Southern California Los Angeles California USA

3. Department of Pediatrics, Division of Environmental Pediatrics New York University School of Medicine New York New York USA

4. Department of Psychiatry and Behavioral Sciences Boston Children's Hospital Boston Massachusetts USA

5. Department of Psychiatry Harvard Medical School Boston Massachusetts USA

6. Department of Pediatrics New York University School of Medicine New York New York USA

7. Icahn School of Medicine at Mount Sinai New York New York USA

8. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

9. Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center University of Colorado Anschutz Medical Campus Aurora Colorado USA

10. Avera Research Institute Sioux Falls South Dakota USA

11. Division of Developmental Neuroscience New York State Psychiatric Institute New York New York USA

12. Department of Pediatrics University of South Dakota School of Medicine Sioux Falls South Dakota USA

13. Department of Preventive Medicine University of Tennessee Health Science Center Memphis Tennessee USA

14. Department of Population Health, Department of Obstetrics & Gynecology University of Kansas School of Medicine Wichita Kansas USA

15. Departments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology University of Rochester Rochester New York USA

16. Department of Pediatrics New York University Grossman School of Medicine New York New York USA

17. Mailman School of Public Health Columbia University Vagelos College of Physicians and Surgeons New York New York USA

18. Departments of Obstetrics and Gynecology Columbia University Irving Medical Center New York New York USA

19. Division of Behavioral Medicine New York State Psychiatric Institute New York New York USA

Abstract

AbstractThis study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental influences on Child Health Outcomes (ECHO) Program from 2009‐2021. GDM, prenatal, and postnatal maternal depressive symptoms were each associated with increased child externalizing and internalizing problems. GDM was associated with increased autism behaviors only among children exposed to perinatal maternal depressive symptoms above the median level. Stratified analyses revealed a relation between GDM and child outcomes in males only.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

NIH Office of the Director

Publisher

Wiley

Subject

Developmental and Educational Psychology,Education,Pediatrics, Perinatology and Child Health

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