Prescription medication use among patients with type 2 diabetes in the United States: 1999–2020

Author:

Li Shanshan12,Pan Shaoxi123,Jiang Shaoxiang1,Shin Jung‐Im45ORCID,Liu Gordon G.126,Lyu Beini1ORCID

Affiliation:

1. Institute for Global Health and Development Peking University Beijing China

2. China Center for Health Economic Research Peking university Beijing China

3. School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education Guizhou Medical University Guiyang China

4. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

5. Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins University Baltimore Maryland USA

6. National School of Development Peking University Beijing China

Abstract

AbstractAimsWe aimed to examine trends in overall prescription medication use among patients with type 2 diabetes in the United States to provide insights for patient care.Materials and MethodsWe used nationally representative data from the National Health and Nutrition Examination Survey from 1999 to 2020 and included adult patients with type 2 diabetes. We examined the use of prescription drugs, overall and by drug class, polypharmacy (use of ≥5 medications), and number of medications attributed to specific classes.ResultsIn the period 2015–2020, the mean patient age was 59.6 (51.0–70.0) years, with 46.8% (43.6–49.9) being female and 57.8% (52.8–62.8) being non‐Hispanic White. Among 9489 adults with type 2 diabetes, the prevalence of polypharmacy was high and increased from 35.1% (31.6–38.6) in 1999–2002 to 47.2% (43.7–50.7) in 2003–2006, and further to 51.1% (48.3–53.9) in 2015–2020 (p for trend <0.001). Increasing trends of polypharmacy were found across all population subgroups and across the majority of therapeutic classes. Use of non‐cardiometabolic medications was common. Among them, the most common were antidepressants (19.8%), proton pump inhibitors (19.0%) and analgesics (16.2%). Among patients with polypharmacy, approximately 40% of medication use was attributed to non‐cardiometabolic medications.ConclusionsPrescription medication burden and complexity increased substantially among patients with type 2 diabetes, with more than 50% of patients with polypharmacy. Attention should be paid to this escalating medication use and regimen complexity, which requires multidisciplinary and coordinated care.

Publisher

Wiley

Reference48 articles.

1. Global Prevalence of Diabetes

2. IDF Diabetes Atlas 2021 | IDF Diabetes Atlas. Accessed August 3 2023.https://diabetesatlas.org/atlas/tenth-edition/.

3. Rapid Increase in the Use of Oral Antidiabetic Drugs in the United States, 1990–2001

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