Bortezomib, C1-Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in Baboons

Author:

Le Bas-Bernardet S.1,Tillou X.1,Branchereau J.1,Dilek N.12,Poirier N.12,Châtelais M.1,Charreau B.1,Minault D.1,Hervouet J.1,Renaudin K.3,Crossan C.4,Scobie L.4,Takeuchi Y.5,Diswall M.6,Breimer M. E.6,Klar N.7,Daha M. R.7,Simioni P.8,Robson S. C.9,Nottle M. B.10,Salvaris E. J.11,Cowan P. J.11,d'Apice A. J. F.11,Sachs D. H.12,Yamada K.12,Lagutina I.13,Duchi R.13,Perota A.13,Lazzari G.13,Galli C.1314,Cozzi E.15,Soulillou J.-P.1,Vanhove B.12,Blancho G.1

Affiliation:

1. Institut de Transplantation- Urologie- Néphrologie (ITUN), Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1064, Centre Hospitalier Universitaire (CHU) de Nantes; Université de Nantes; Nantes France

2. Effimune; Nantes France

3. Pathology Laboratory; CHU- Hôtel Dieu; Nantes France

4. Department of Biological and Biomedical Sciences; Glasgow Caledonian University; Glasgow United Kingdom

5. Medical Research Council Centre for Medical Virology and Division of Infection and Immunity, Wohl Virion Centre; University College London; London United Kingdom

6. Department of Surgery, Institute of Clinical Sciences; Sahlgrenska Academy at University of Gothenburg; Gothenburg Sweden

7. Department of Nephrology; University Medical Center; Leiden the Netherlands

8. Department of Cardiologic, Thoracic and Vascular Sciences; University of Padua; Padua Italy

9. Gastroenterology and Transplant Institute, Department of Medicine; Beth Israel Deaconess Medical Center; Harvard Medical School; Boston MA

10. Robinson Institute, School of Paediatrics and Reproductive Health; University of Adelaide; Adelaide Australia

11. Immunology Research Centre; St Vincent's Hospital Melbourne; Victoria Australia

12. Transplantation Biology Research Center (TBRC); Massachusetts General Hospital, and Harvard Medical School; Boston MA

13. Avantea; Cremona Italy

14. Department of Veterinary Medical Science; University of Bologna; Ozzano Emilia Italy

15. Transplant Immunology Unit, Padua General Hospital, Padua; Italy and Consortium for Research in Organ Transplantation (CORIT); Padua Italy

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference49 articles.

1. The generation of transgenic pigs as potential organ donors for humans;Cozzi;Nat Med,1995

2. Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons;Cowan;Transplantation,2000

3. Progress and prospects: Genetic engineering in xenotransplantation;Le Bas-Bernardet;Gene Ther,2008

4. Xenogeneic thyroid-stimulating hormone-like activity of the human natural anti-Gal antibody. Interaction of anti-Gal with porcine thyrocytes and with recombinant human thyroid-stimulating hormone receptors expressed on mouse cells;Winand;J Immunol,1993

5. Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs;Dai;Nat Biotechnol,2002

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