Pimasertib, a selective oral MEK1/2 inhibitor: absolute bioavailability, mass balance, elimination route, and metabolite profile in cancer patients

Author:

von Richter Oliver1,Massimini Giorgio2,Scheible Holger3,Udvaros Istvan4,Johne Andreas1

Affiliation:

1. Merck KGaA; Clinical Pharmacology; 64293 Darmstadt Germany

2. Merck KGaA; Early Clinical Oncology; 64293 Darmstadt Germany

3. Merck KGaA; DMPK; 85567 Grafing Germany

4. PRA International; EDS Patient Pharmacology; 1076 Budapest Hungary

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference27 articles.

1. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands;Southan;Nucl Acids Res,2016

2. The Concise Guide to PHARMACOLOGY 2015/16: Enzymes;Alexander;Br J Pharmacol,2015

3. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo;Kim;Br J Haematol,2010

4. World Intellectual Property Organization WO2006045514. 3-arylamino pyridine derivatives 2006 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2006045514&redirectedID=true

5. World Intellectual Property Organization WO2013178320. Solid state forms of n-((s)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide 2013 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013178320&redirectedID=true

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