Affiliation:
1. Shunde Hospital Guangzhou University of Chinese Medicine Foshan China
2. Graduate School Beijing University of Chinese Medicine Beijing China
3. Department of Integrative Oncology China‐Japan Friendship Hospital Beijing China
4. Guangzhou University of Chinese Medicine Guangzhou China
Abstract
AbstractAn association between venous leg ulcers (VLU) and chronic heart failure (CHF) has been suggested by observational research. This study used Mendelian randomization (MR) methods to look into any possible bidirectional causal links between VLU and CHF. The ‘TwoSampleMR’ R package was employed for MR analyses. The association of VLU and CHF was assessed via methods of inverse variance weighted (IVW), weighted mode, MR Egger and weighted median. Results of IVW suggested no association between VLU and CHF (β 0.008356; SE 0.01889; p = 0.6582). The weighted median estimator (β −0.005777; SE 0.02059, p = 0.7791), MR‐Egger (β −0.08955; SE 0.04557; p = 0.07296) and weighted mode (β −0.01202; SE 0.02467; p = 0.6341) showed consistent results. Conversely, evidence indicating that the presence of CHF increased the risk of VLU was lacking. In conclusion, there is no bidirectional causal relationship between VLU and CHF. Further studies are required to validate the findings of this study.
Reference21 articles.
1. Venous ulcers: diagnosis and treatment;Bonkemeyer Millan S;Am Fam Physician,2019
2. The 2020 update of the CEAP classification system and reporting standards
3. Epidemiology of chronic venous disorders in geographically diverse populations: results from the Vein consult program;Rabe E;Int Angiol,2012
4. How health literacy relates to venous leg ulcer healing: A scoping review
5. A literature review of pharmacological agents to improve venous leg ulcer healing;Kitchens BP;Wounds,2020