Affiliation:
1. Programa de Pós‐Graduação em Ciências Biológicas: Neurociências, Instituto de Ciências Básicas da Saúde Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil
2. Programa de Pós‐Graduação em Biologia Universidade do Vale do Rio dos Sinos (UNISINOS) São Leopoldo Brazil
3. Departamento de Farmacociências Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) Porto Alegre Brazil
4. Laboratório de Bioquímica, Fisiologia e Farmacologia, Faculdade de Medicina Veterinária, Instituto de Medicina Veterinária Campus Universitário de Castanhal, Universidade Federal do Pará (UFPA) Castanhal Brazil
Abstract
AbstractAlthough Place Conditioning (PC) has been used to study the motivational effects of alcohol for almost 50 years, variables and situations in which alcohol induces PC in rats are still unclear, especially for short PC protocols (up to 10 conditioning trials). The aim of this systematic review was to predict primary outcomes (namely, conditioning failure, conditioned place aversion (CPA), and conditioned place preference (CPP)) of alcohol‐induced PC with male outbred rats. We sought relevant records in PUBMED and two other sources. Two reviewers independently assessed records for eligible articles (those meeting all inclusion criteria), selected alcohol‐induced PC experiments (those meeting no exclusion criteria) from eligible articles, extracted data, and assessed the quality of included studies. We then conducted a predictive analysis of outcomes by examining procedure‐outcome relations according to variables known to affect associative learning, alcohol interventions in rats, and PC interventions themselves. We selected 192 experiments (133 short protocols, 27 long protocols, and 32 protocols with alcohol pre‐exposure) from 62 articles to compose the review. Rates of conditioning failure are mainly predicted by interactions of alcohol dose and the number of habituation sessions and conditioning trials. Different conditions (housing systems) and characteristics (age and weight) of animals predict CPA and CPP: higher rates of CPA are predicted by single‐housed, older, and heavier animals, while higher rates of CPP are predicted by group‐housed, younger, and lighter animals. We recommend settings for CPP induction in short protocols, discuss the broad theoretical and translational consequences of the predictive analysis for the use of PC in alcohol research, and specify variables needing more careful investigation. This review could improve our understanding of the results of alcohol‐induced PC with rats, refine our understanding of the motivational function of alcohol and alcohol‐seeking behavior triggered by environmental contexts, and open new avenues of research on their neurobiological basis.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献