The habits of European urologists in the field of cryopreservation before the urological cancers treatment

Author:

Degraeve Amandine12ORCID,Roumeguere Thierry3ORCID,Tilmans Gilles4,Marotta Marie‐Laura5,Huyghe Eric678,Fournier Georges9,Faix Antoine10,Spinoit Anne‐Françoise11,Decaestecker Karel11,Herve François11,Boitrelle Florence1213ORCID,Lahdensuo Kanerva14,Tosco Lorenzo3,Van Damme Julien2,

Affiliation:

1. Department of Urology Centre Hospitalier Universitaire Université Catholique de Louvain Namur Belgium

2. Department of Urology Cliniques Universitaires Saint‐Luc Bruxelles Belgium

3. Department of Urology Université libre de Bruxelles (ULB) Hôpital Universitaire de Bruxelles (H.U.B) Erasme Hospital Brussels Belgium

4. Unit of Abdominal Surgery Saint‐Luc University Clinics Université Catholique de Louvain Brussels Belgium

5. Department of Andrology Centre Hospitalier Universitaire Université Catholique de Louvain Namur Belgium

6. Department of Urology—Kidney transplantation—Andrology—Rangueil Hopital Centre Hospitalier Universitaire de Toulouse Toulouse France

7. Department of Reproductive Medicine Paule de Viguier Hospital Centre Hospitalier Universitaire de Toulouse Toulouse France

8. UMR 1203 « DEFE » (Development—Embryo—Fertility—Environment) —INSERM—Université de Toulouse—Université de Montpellier Montpellier France

9. Department of Urology University of Brest Brest France

10. Department of Urology Clinique Beau Soleil Montpellier France

11. Department of Urology Ghent University Hospital Ghent Belgium

12. Reproductive Biology Fertility Preservation Andrology, CECOS, Poissy Hospital Poissy France

13. Paris Saclay University, UVSQ, INRAE, BREED Jouy‐en‐Josas France

14. Department of Urology and Research Program in Systems Oncology University of Helsinki and Helsinki University Hospital Helsinki Finland

Abstract

AbstractIntroductionTreatments against urogenital cancers frequently have fertility side‐effects. The strategy to preserve fertility after oncologic treatments is still a matter of debate with a lack of evidence and international guidelines. The aim of this study is to investigate fertility preservation practices before urogenital cancer treatments and to compare national habits.Material and methodsAn online anonymous survey was submitted from January to June 2021 to six European urological societies. The 31‐items questionnaire included questions about demography, habits of evaluation, and management of fertility preservation in case of urogenital cancer treatments.ResultsTwo hundred twenty‐eight urologists from six urological societies in five different countries (Belgium, The Netherlands, Luxembourg, France, Finland) filled out the survey.Three quarter (74%; n = 166) usually propose a cryopreservation before orchidectomy. In case of oligo/azoo‐spermia, the technique performed for the sperm extraction during orchidectomy varies among the sample: 70.5% (n = 160) of the responders do not perform a Testicular Sperm Extraction (TESE) nor a Percutaneous Epididymal Sperm Aspiration (PESA).The cryopreservation for prostate cancer treatments is never proposed in 48.17% (n = 105) of responders but conversely it is always proposed in 5.05% (n = 11).The cryopreservation before bladder cancer treatments is not commonly proposed (67.5%, n = 154).ConclusionOur study showed variable country specific tendencies in terms of fertility preservation in the period of treatment of urological cancers. These differences seem to be related to national guidelines recommendations. Standardization of international guidelines is urgently needed in the field of fertility for urological cancer patients.

Publisher

Wiley

Subject

Urology,Endocrinology,Reproductive Medicine,Endocrinology, Diabetes and Metabolism

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