Affiliation:
1. Department of Surgery UT Southwestern Medical Center Dallas Texas USA
2. Centre de Recherche des Cordeliers Equipe labellisée par la Ligue contre le cancer Université Paris Cité Sorbonne Université INSERM U1138 Institut Universitaire de France Paris France
3. Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Campus Villejuif France
4. Institut du Cancer Paris CARPEM Department of Biology Hôpital Européen Georges Pompidou, AP‐HP Paris France
Abstract
SummaryFerroptosis is a form of iron‐dependent regulated cell death characterized by the accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic cell death. While it plays a crucial role in maintaining the overall health and proper functioning of multicellular organisms, it can also contribute to tissue damage and pathological conditions. Although ferroptotic damage is generally recognized as an immunostimulatory process associated with the release of damage‐associated molecular patterns (DAMPs), the occurrence of ferroptosis in immune cells or the release of immunosuppressive molecules can result in immune tolerance. Consequently, there is ongoing exploration of targeting the upstream signals or the machinery of ferroptosis to therapeutically enhance or inhibit the immune response. In addition to introducing the core molecular mechanisms of ferroptosis, we will focus on the immune characteristics of ferroptosis in pathological conditions, particularly in the context of infection, sterile inflammation, and tumor immunity.
Funder
National Institutes of Health
Ligue Contre le Cancer
Agence Nationale de la Recherche
Fondation pour la Recherche Médicale
CNIB
Subject
Immunology,Immunology and Allergy
Cited by
7 articles.
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