Affiliation:
1. Emergency Department Gulou Hospital of Traditional Chinese Medicine of Beijing Beijing China
2. Emergency Department, Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing China
Abstract
ABSTRACTMicroRNA (miRNA) shows promise as a biomarker for sepsis diagnosis and prognosis. In the present investigation, we examined the potential of miR‐181a‐5p as a clinical diagnostic and prognostic indicator for sepsis. This study enrolled 119 sepsis patients and 125 controls. Serum miR‐181a‐5p levels were assessed via RT‐qPCR, revealing a significant upregulation in sepsis patients. The receiver operating characteristic (ROC) curve indicated miR‐181a‐5p could distinguish sepsis patients with 73.11% sensitivity and 89.60% specificity (AUC = 0.879). Pearson's analysis showed serum miR‐181a‐5p positively correlated with disease severity scores (APACHE II and SOFA), procalcitonin (PCT), C‐reactive protein (CRP), tumor necrosis factor‐alpha (TNF‐α), interleukin 6 (IL‐6), malondialdehyde (MDA), and negative with glutathione peroxidase (GSH‐Px). Kaplan–Meier survival analysis revealed that elevated serum miR‐181a‐5p levels were associated with a worse 28‐day prognosis in sepsis patients (log‐rank p = 0.022). In summary, this study identifies serum miR‐181a‐5p as a diagnostic and prognostic biomarker for sepsis, significantly linked to disease severity, inflammation, and oxidative stress, providing new avenues for sepsis management.