The value of FDG combined with PiB PET in the diagnosis of patients with cognitive impairment in a memory clinic

Author:

Liu Fang1,Shi Yudi12,Wu Qiuyan1,Chen Huifeng13,Wang Ying4,Cai Li4,Zhang Nan13ORCID

Affiliation:

1. Department of Neurology Tianjin Neurological Institute, Tianjin Medical University General Hospital Tianjin China

2. Health Management Center Tianjin Medical University General Hospital Airport Site Tianjin China

3. Department of Neurology Tianjin Medical University General Hospital Airport Site Tianjin China

4. PET/CT Center Tianjin Medical University General Hospital Tianjin China

Abstract

AbstractAimsTo analyze the value of 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis.MethodsA total of 187 patients with dementia or mild cognitive impairment (MCI) who underwent 11C‐Pittsburgh compound B (PiB) and FDG PET scans in a memory clinic were included in the final analysis.ResultsAmyloid‐positive and amyloid‐negative dementia patient groups showed a significant difference in the proportion of individuals presenting temporoparietal cortex (p < 0.001) and posterior cingulate/precuneus cortex (p < 0.001) hypometabolism. The sensitivity and specificity of this hypometabolic pattern for identifying amyloid pathology were 72.61% and 77.97%, respectively, in patients clinically diagnosed with AD and 60.87% and 76.19%, respectively, in patients with MCI. The initial diagnosis was changed in 32.17% of patients with dementia after considering both PiB and FDG results. There was a significant difference in both the proportion of patients showing the hypometabolic pattern and PiB positivity between dementia conversion patients and patients with a stable diagnosis of MCI (p < 0.05).ConclusionTemporoparietal and posterior cingulate/precuneus cortex hypometabolism on FDG PET suggested amyloid pathology in patients with cognitive impairment and is helpful in diagnostic decision‐making and predicting AD dementia conversion from MCI, particularly when combined with amyloid PET.

Publisher

Wiley

Subject

Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology

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