Effects of Hypericum perforatum (St John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans

Author:

Scholz Irene12,Liakoni Evangelia12ORCID,Hammann Felix12ORCID,Grafinger Katharina Elisabeth12ORCID,Duthaler Urs34ORCID,Nagler Michael5,Krähenbühl Stephan134,Haschke Manuel12ORCID

Affiliation:

1. Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital University of Bern Switzerland

2. Institute of Pharmacology University of Bern Switzerland

3. Division of Clinical Pharmacology & Toxicology University Hospital Basel Switzerland

4. Department of Biomedicine University of Basel Switzerland

5. University Institute of Clinical Chemistry, Inselspital, Bern University Hospital Switzerland

Funder

Bayer

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference60 articles.

1. European Medical Agency European Public assessment Report: Xarelto.https://www.ema.europa.eu/en/medicines/human/EPAR/xarelto

2. Novel oral anticoagulants: clinical pharmacology, indications and practical considerations

3. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor

4. Importance of Pharmacokinetic Profile and Variability as Determinants of Dose and Response to Dabigatran, Rivaroxaban, and Apixaban

5. Xarelto SUMMARY OF PRODUCT CHARACTERISTICS.https://www.ema.europa.eu/en/documents/product-information/xarelto-epar-product-information_en.pdf(accessed August 2020).

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