Affiliation:
1. Department of Medical Immunology, College of Basic Medical Sciences Yan'an University Yan'an China
2. Clinical Teaching and Research Center, School of Nursing Weinan vocational and technical college Weinan China
3. Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences Xi'an Jiaotong University Xi'an Shaanxi China
4. Xi'an Jiaotong University Health Science Center, Institute of Infection and Immunity, Translational Medicine Institute Xi'an Shaanxi China
5. Key Laboratory of Environment and Genes Related to Diseases Xi'an Jiaotong University Xi'an Shaanxi China
Abstract
AbstractT cells are crucial for adaptive immunity to regulate proper immune response and immune homeostasis. T cell development occurs in the thymus and mainly differentiates into CD4+ and CD8+ T cell subsets. Upon stimulation, naive T cells differentiate into distinct CD4+ helper and CD8+ cytotoxic T cells, which mediate immunity homeostasis and defend against pathogens or tumours. Trace elements are minimal yet essential components of human body that cannot be overlooked, and they participate in enzyme activation, DNA synthesis, antioxidant defence, hormone production, etc. Moreover, trace elements are particularly involved in immune regulations. Here, we have summarized the roles of eight essential trace elements (iron, zinc, selenium, copper, iodine, chromium, molybdenum, cobalt) in T cell development, activation and differentiation, and immune response, which provides significant insights into developing novel approaches to modulate immunoregulation and immunotherapy.
Funder
Key Research and Development Projects of Shaanxi Province
National Key Research and Development Program of China Stem Cell and Translational Research
Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China