The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics andIn VivoFormation of the Major Metabolites in Rats-Reference-Cited by-同舟云学术

The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics andIn VivoFormation of the Major Metabolites in Rats

Published:2017-12-15 Issue:4 Volume:122 Page:373-382
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:Basic Clin Pharmacol Toxicol

Author:

Zdarova Karasova Jana¹²,Mzik Martin³,Hroch Milos⁴,Korabecny Jan¹²,Nepovimova Eugenie¹,Vorisek Viktor³,Palicka Vladimir³,Kuca Kamil²⁵

Affiliation:

1. Department of Toxicology and Military Pharmacy; Faculty of Military Health Sciences; University of Defense; Hradec Kralove Brno Czech Republic

2. Biomedical Research Center; University Hospital; Hradec Kralove Czech Republic

3. Institute of Clinical Biochemistry and Diagnostic; University Hospital; Hradec Kralove Czech Republic

4. Department of Medical Biochemistry; Faculty of Medicine in Hradec Kralove; Charles University; Hradec Kralove Czech Republic

5. Department of Cellular Biology and Pharmacology; Florida International University; Miami FL USA

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcpt.12922/fullpdf

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5. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil;van Greunen;Eur J Med Chem,2017

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