A systematic review on the applicability of cell‐free DNA level as an obesity biomarker

Author:

Tung Keith T. S.1,Tsang Hing Wai1,Ngo Ulrike1,Wong Rosa S.12,Chow Clare H. Y.1,Tso Winnie H. Y.13,Yam Jason C. S.34,Chan Godfrey C. F.13,Ip Patrick13ORCID

Affiliation:

1. Department of Paediatrics and Adolescent Medicine The University of Hong Kong Hong Kong SAR, China

2. Department of Special Education and Counselling (SEC) The Education University of Hong Kong Hong Kong SAR China

3. Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital Hong Kong SAR, China

4. Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong SAR, China

Abstract

SummaryObesity has become a global health concern in recent decades. Utilizing biomarkers presents a promising approach to comprehensively monitor the progress of obesity and its associated health conditions. This review aims to synthesize the available evidence on the correlation between cfDNA level and obesity and to provide insights into the applicability of using cfDNA level as a tool for monitoring progression of obesity. Searches were performed in PubMed and Embase on April 1, 2022. Data and other relevant information were extracted and compiled into a structured table for further analysis. Among 1170 articles screened, 11 articles were included in this review and assessed qualitatively. The results demonstrated that existing evidence mainly focused on three populations, including healthy individuals, cancer patients and pregnant women. Majority of the studies on healthy individuals identified a significant association between cfDNA level and body weight status but not among cancer patients. Varying results were observed among pregnant women at different gestational trimesters. Our review summarized some preliminary evidence on the association between cfDNA level and obesity. More cohort studies in larger scale with comprehensive assessment have to be conducted to examine the applicability of cfDNA as a biomarker for severity and disease progression of obesity.

Publisher

Wiley

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