Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases

Author:

Zhang Dong-Yang12,Zhang Chun-Feng12,Fu Bi-Cheng12,Sun Lu12,Wang Xue-Qing12,Chen Wei12,Liu Wei2,Liu Kai-Yu12,Du Guo-Qing2,Ma Chong-Yi12,Jiang Shu-Lin12,Li Ren-Ke34ORCID,Tian Hai12

Affiliation:

1. Department of Cardiovascular Surgery; Second Affiliated Hospital of Harbin Medical University; Harbin Heilongjiang China

2. Key Laboratory of Myocardial Ischemia; Harbin Medical University; Ministry of Education; Harbin Heilongjiang China

3. Toronto General Hospital Research Institute; University Health Network; Toronto Ontario Canada

4. Department of Surgery; University of Toronto; Toronto Ontario Canada

Funder

Natural Science Foundation of Heilongjiang Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference32 articles.

1. Heart disease and stroke statistics-2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee;Thom;Circulation,2006

2. Prognostic value of reverse left ventricular remodeling after primary angioplasty for STEMI;Carrabba;Atherosclerosis,2012

3. Clinical implications of early mitral regurgitation in patients with reperfused acute myocardial infarction;Carrabba;J Card Fail,2008

4. Aging and disease as modifiers of efficacy of cell therapy;Dimmeler;Circ Res,2008

5. Cell transplantation improves ventricular function after a myocardial infarction: a preclinical study of human unrestricted somatic stem cells in a porcine model;Kim;Circulation,2005

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