Affiliation:
1. Department of Cardiology First Hospital of Shanxi Medical University Taiyuan China
2. First Clinical Medical College Shanxi Medical University Taiyuan China
3. Clinical Research Center, Shenzhen Evergreen Medical Institute Shenzhen China
4. Shenzhen International Graduate School Tsinghua University Shenzhen China
5. Department of Neurosurgery First Affiliated Hospital of Kangda College of Nanjing Medical University Lianyungang China
6. Department of Cardiology Peking University First Hospital Beijing China
Abstract
AbstractBackground and purposeHypertension significantly contributes to stroke. Previous research has indicated a connection between daytime napping and stroke. Research on the connection between daytime napping duration and first stroke in hypertensive individuals is lacking nevertheless.MethodsThis research, which ran from 24 August 2013 to 31 December 2022, recruited 11,252 individuals with hypertension and without a history of stroke from the China Stroke Primary Prevention Trial. To determine the relationship between daytime napping duration and stroke onset in hypertensive individuals, we conducted analyses for threshold effects, multivariate‐adjusted Cox proportional hazard regression models, and Kaplan–Meier survival curves.ResultsThe duration of daytime napping (<75 min) was positively correlated with stroke risk; beyond 75 min, the risk did not increase further. When compared to hypertensive individuals who napped for 1–30 min, daytime napping 31–60 min (hazard ratio [HR] = 1.27, 95% confidence interval [CI] = 1.06–1.53) and >60 min (HR = 1.37, 95% CI = 1.14–1.65) were substantially related with a greater risk of first stroke. Additionally, this correlation was absent in cases of hemorrhagic stroke, but present in cases of ischemic stroke, specifically for hypertensive individuals who napped for 31–60 min or >60 min (p < 0.05). Kaplan–Meier survival curves displayed that hypertensive individuals who extended daytime napping had an elevated incidence of stroke.ConclusionsHypertensive individuals who take longer daytime naps (>30 min) are at an elevated risk of stroke onset, particularly ischemic stroke, irrespective of other factors.
Funder
Development and Reform Commission of Shenzhen Municipality
National Key Research and Development Program of China