Affiliation:
1. Department of Public Health and Preventive Medicine, School of Medicine Jinan University Guangzhou Guangdong China
2. Department of Hepatobiliary Surgery The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia China
3. Helmholtz Zentrum München‐German Research Center for Environmental Health Institute of Epidemiology Neuherberg PR Germany
4. General Surgery The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia China
5. Department of Infectious Disease Shenzhen Qianhai Shekou Free Trade Zone Hospital Shenzhen China
6. Shenzhen Qianhai Shekou Free Zone Hospital Shenzhen China
7. Department of Food Science and Nutrition The Hong Kong Polytechnic University Kowloon Hong Kong China
8. Research Institute for Future Food The Hong Kong Polytechnic University Kowloon Hong Kong China
Abstract
SummaryThe present systematic review and meta‐analysis aimed to summarize the associations between gut microbiota composition and non‐alcoholic fatty liver disease. To compare the differences between individuals with or without NAFLD, the standardized mean difference and 95% confidence interval were computed for each α‐diversity index and relative abundance of gut microbes. The β‐diversity indices were summarized in a qualitative manner. A total of 54 studies with 8894 participants were included. Overall, patients with NAFLD had moderate reduction in α‐diversity indices including Shannon (SMD = −0.36, 95% CI = [−0.53, −0.19], p < 0.001) and Chao 1 (SMD = −0.42, 95% CI = [−0.68, −0.17], p = 0.001), but no significant differences were found for Simpson, observed species, phylogenetic diversity, richness, abundance‐based coverage estimator, and evenness (p ranged from 0.081 to 0.953). Over 75% of the included studies reported significant differences in β‐diversity. Although there was substantial interstudy heterogeneity, especially for analyses at the phylum, class, and family levels, the majority of the included studies showed alterations in the depletion of anti‐inflammatory microbes (i.e., Ruminococcaceae and Coprococcus) and the enrichment of proinflammatory microbes (i.e., Fusobacterium and Escherichia) in patients with NAFLD. Perturbations in gut microbiota were associated with NAFLD, commonly reflected by a reduction in beneficial species and an increase in the pathogenic species.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province
National Natural Science Foundation of China
Subject
Public Health, Environmental and Occupational Health,Endocrinology, Diabetes and Metabolism