<scp>CLA</scp><sup>+</sup> memory T cells in atopic dermatitis-Reference-Cited by-同舟云学术

CLA⁺ memory T cells in atopic dermatitis

Published:2023-07-13 Issue:1 Volume:79 Page:15-25
ISSN:0105-4538
Container-title:Allergy
language:en
Short-container-title:Allergy

Author:

Nicolàs Lídia Sans‐de San¹^ORCID,Czarnowicki Tali²,Akdis Mübeccel³^ORCID,Pujol Ramon M.⁴,Lozano‐Ojalvo Daniel⁵^ORCID,Leung Donald Y. M.⁶^ORCID,Guttman‐Yassky Emma⁵^ORCID,Santamaria‐Babí Luis F.¹^ORCID

Affiliation:

1. Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB) Parc Científic de Barcelona (PCB) Barcelona Spain

2. Shaare Zedek Medical Center The Hebrew University of Jerusalem Jerusalem Israel

3. Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos‐Wolfgang Switzerland

4. Departament de Dermatologia, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) Universitat Autònoma de Barcelona (UAB) Barcelona Spain

5. Department of Dermatology Icahn School of Medicine at Mount Sinai New York New York USA

6. Department of Pediatrics National Jewish Health Denver Colorado USA

Abstract

AbstractCirculating skin‐homing cutaneous lymphocyte‐associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL‐13, IL‐31, pruritus, CCL17 and early effects on dupilumab‐treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin‐associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.

Funder

European Regional Development Fund

Instituto de Salud Carlos III

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.15816

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