Walking the tightrope: proteostasis and neurodegenerative disease

Author:

Yerbury Justin J.12,Ooi Lezanne12,Dillin Andrew34,Saunders Darren N.56,Hatters Danny M.7,Beart Philip M.8,Cashman Neil R.9,Wilson Mark R.12,Ecroyd Heath12

Affiliation:

1. Proteostasis and Disease Research Centre; School of Biological Sciences; Faculty of Science, Medicine and Health; University of Wollongong; Wollongong New South Wales Australia

2. Illawarra Health and Medical Research Institute; Wollongong; New South Wales Australia

3. Department of Molecular and Cell Biology; Li Ka Shing Center for Biomedical and Health Sciences; The University of California; California USA

4. Howard Hughes Medical Institute; The University of California; Berkeley California USA

5. School of Medical Sciences; Faculty of Medicine; University of New South Wales; Randwick New South Wales Australia

6. The Kinghorn Cancer Centre; Garvan Institute of Medical Research; Darlinghurst New South Wales Australia

7. Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute; University of Melbourne; Parkville Victoria Australia

8. Florey Institute of Neuroscience and Mental Health; University of Melbourne; Parkville Victoria Australia

9. Department of Medicine (Neurology); University of British Columbia and Vancouver Coastal Health Research Institute; Brain Research Centre; University of British Columbia; Vancouver British Columbia Canada

Funder

ARC DECRA

ARC Future Fellowship

NHMRC Research Fellowship

Victorian State Government

Garvan Research Foundation

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference164 articles.

1. A molecular chaperone complex at the lysosomal membrane is required for protein translocation;Agarraberes;J. Cell Sci.,2001

2. Heat shock factors: integrators of cell stress, development and lifespan;Akerfelt;Nat. Rev. Mol. Cell Biol.,2010

3. Regulation of HSF1 function in the heat stress response: implications in aging and disease;Anckar;Annu. Rev. Biochem.,2011

4. Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice;Anderson;J. Neurochem.,2005

5. Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity;Anyanful;Cell Host Microbe,2009

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