Affiliation:
1. Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences Zhejiang University Hangzhou China
2. School of Pharmacy Hangzhou Medical College Hangzhou China
3. Jinhua Institute of Zhejiang University Jinhua China
Abstract
AbstractAimsMania is a prevalent psychiatric disorder with undefined pathological mechanism. Here, we reviewed current knowledge indicating the potential involvement of autophagy dysregulation in mania and further discussed whether targeting autophagy could be a promising strategy for mania therapy.DiscussionsAccumulating evidence indicated the involvement of autophagy in the pathology of mania. One of the most well‐accepted mechanisms underlying mania, circadian dysregulation, showed mutual interaction with autophagy dysfunction. In addition, several first‐line drugs for mania therapy were found to regulate neuronal autophagy. Besides, deficiencies in mitochondrial quality control, neurotransmission, and ion channel, which showed causal links to mania, were intimately associated with autophagy dysfunction.ConclusionsAlthough more efforts should be made to either identify the key pathology of mania, the current evidence supported that autophagy dysregulation may act as a possible mechanism involved in the onset of mania‐like symptoms. It is therefore a potential strategy to treat manic disorder by correting autophagy.
Funder
Natural Science Foundation of Zhejiang Province
Subject
Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology