The role of candidate transport proteins in β‐cell long‐chain fatty acid uptake: Where are we now?

Author:

Clavelo‐Farrow Christina1,Thomas Patricia1ORCID

Affiliation:

1. Institute of Metabolism and Systems Research, University of Birmingham Birmingham UK

Abstract

AbstractType 2 diabetes (T2D) in humans is typically preceded by elevated levels of circulatory long‐chain free fatty acids (LC‐FFA). These excess LC‐FFA are widely thought to be taken up by pancreatic β‐cells, contributing to their dysfunction and death during the development of T2D; a process that has been termed lipotoxicity. Depending on their degree of saturation and carbon chain length, LC‐FFA can exert different effects on pancreatic β‐cells viability and function in vitro. Long‐chain saturated fatty acids (LC‐SFA) are thought to be toxic, whereas monounsaturated fatty acids are not and may even offer protection against the toxic effects of LC‐SFAs. However, the mechanism of LC‐FFA uptake into pancreatic β‐cells is poorly understood, partly because it has been an understudied area of research. Determining how LC‐FFA are taken up into β‐cells is crucial for later formulation of therapies to prevent potential cellular overload of LC‐FFA, thereby slowing the onset of T2D. In this work, we detail more than 40 years of literature investigating the role of membrane‐associated transport proteins in LC‐FFA uptake. By focussing on what is known in other cell types, we highlight where we can extrapolate our current understanding of protein‐mediated transport to β‐cells and uncover where further understanding is required.

Funder

Medical Research Council

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Basic science lays the foundation to success;Diabetic Medicine;2023-11-10

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3