The role of T cells and myeloid‐derived suppressor cells in refractory immune thrombocytopenia

Author:

Yazdanbakhsh Karina1ORCID,Provan Drew2ORCID,Semple John W.345ORCID

Affiliation:

1. Laboratory of Complement Biology Lindsley F. Kimball Research Institute, New York Blood Center New York New York USA

2. Department of Haematology Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London London UK

3. Division of Hematology and Transfusion Medicine Lund University Lund Sweden

4. Clinical Immunology and Transfusion Medicine Office of Medical Services, Region Skåne Lund Sweden

5. Department of Pharmacology University of Toronto Toronto Ontario Canada

Abstract

SummaryImmune thrombocytopenia (ITP) is characterized by a dysregulated immune response against platelets, affecting both their destruction and production. A role for an abnormal T‐cell compartment has been established in ITP pathogenesis and treatments that increase platelet counts in patients with ITP have shown improvements in T‐cell profiles. On the other hand, patients who were refractory to treatment appear to retain the T‐cell abnormalities as before. Myeloid‐derived suppressive cells (MDSCs) are also emerging as key contributors to the immune pathology of ITP and response to treatment. In this review, we will discuss how various treatments affect the T‐cell and MDSC compartments in ITP. The review will focus on studies that have examined the underlying mechanisms and/or genetic basis responsible for refractoriness to a given treatment and highlight remaining challenges in identifying factors and mechanisms to predict response to treatment.

Funder

Vetenskapsrådet

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Hematology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3