European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for appendiceal neuroendocrine tumours (aNET)

Author:

Kaltsas Gregory1ORCID,Walter Thomas2,Knigge Ulrich3,Toumpanakis Christos4,Santos Ana P.5ORCID,Begum Nehara6,Pape Ulrich F.7,Volante Marco8,Frilling Andrea9,Couvelard Anne10

Affiliation:

1. 1st Propaedeutic Department of Internal Medicine National and Kapodistrian University of Athens Athens Greece

2. Department of Medical Oncology Edoard Herriot Hospital Lyon France

3. Departments of Surgery and Clinical Endocrinology, ENETS Centre of Excellence Copenhagen University Hospital Copenhagen Denmark

4. Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Centre of Gastroenterology Royal Free Hospital London UK

5. Department of Endocrinology, Portuguese Oncology Institute of Porto (IPO Porto) Porto Comprehensive Cancer Centre (P.CCC) Porto Portugal

6. Department of General‐, Visceral‐, Thoracic‐ and Endocrine Surgery Johannes Wesling Klinikum Minden Minden Germany

7. Department of Internal Medicine and Gastroenterology Asklepios Klinik St. Georg, Asklepios Tumorzentrum Hamburg Germany

8. Department of Oncology, Pathology Unit University of Turin Turin Italy

9. Department of Surgery and Cancer Imperial College London London UK

10. Department of Pathology‐Bichat Hospital AP‐HP and Université Paris Cité Paris France

Abstract

AbstractThe aim of the present guidance paper is to update the previous ENETS guidelines on well differentiated appendiceal neuroendocrine tumours (NET), providing practical guidance for the diagnosis and management of appendiceal NET (aNET); poorly differentiated neoplasms are dealt with in a separate guidance paper. This paper is structured on a question‐answer format in order to also address controversial issues and areas where uncertainty regarding the management and follow‐up of aNET exists. All recommendations are offered on the basis of the best available evidence, along with the authors' experiences in managing these neoplasms. Each recommendation for treatment will provide a level of evidence and grade of recommendation as per the GRADE system (adapted in Infectious Disease Society of United States Public Health Service grading system).

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

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