Affiliation:
1. Department of Pharmacy, Chelsea College (University of London), Manresa Road, London SW3 6LX, U.K.
Abstract
Abstract
Five size fractions of sulphathiazole powder (volume surface mean diameter 155, 133, 86, 50 and 41 μm) were compressed into 12 mm diameter tablets on an instrumented single punch tablet machine. The size analysis of the tablet material after compression showed an attrition of the coarser fraction and an agglomeration of the finer fraction. It is postulated that there is a critical particle size where the effects of crushing and bonding cancel each other. The changes in particle size are discussed in relation to some of the compressive characteristics of the powder.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
32 articles.
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