Affiliation:
1. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, V6T 1Z3 Canada
Abstract
Abstract
Capping and lamination occur when the bonds within a tablet cannot withstand the elastic recovery during decompression. To estimate tablet recovery, it is necessary to subtract the machine recovery from the total recovery during decompression. A direct relationship between the force and machine deformation is applied in a novel fashion to calculate in-die tablet recovery on a Manesty Betapress and to estimate the Young's modulus, E, of various solids from the recovery data. The E values of about twenty-five pharmaceutical solids were found to be in reasonable agreement with literature values. This procedure allows in-process analysis of tablet recovery and gives E without the use of specialized equipment.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference47 articles.
1. Theophylline hydrate/anhydrous system: effects of water of hydration on mechanical properties of compacted beams;Agbada;J. Pharm. Pharmacol.,1990
2. Strain recovery of compacts on extended storage;Aulton;J. Pharm. Pharmacol.,1973
3. Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures;Bangudu;J. Pharm. Pharmacol.,1985
4. Effect of particle size and source on variability of Young's modulus of microcrystalline cellulose powders;Bassam;J. Pharm. Pharmacol.,1988
Cited by
30 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献