Unusual solubility behaviour of cyclosporin A in aqueous media-Reference-Cited by-同舟云学术

Unusual solubility behaviour of cyclosporin A in aqueous media

Published:1991-04 Issue:4 Volume:43 Page:287-289
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Ismailos George¹,Reppas Christos¹,Dressman Jennifer B²,Macheras Panayotis¹

Affiliation:

1. Department of Pharmacy, University of Athens, Athens 106 80, Greece and

2. College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065, USA

Abstract

Abstract The solubility of cyclosporin A was determined in water and in Sorensen buffers at pH 1.2 and 6.6 at temperatures ranging from 5 to 37°C. No differences in solubility behaviour were observed among the three aqueous media. Solubility was found to be inversely proportional to the temperature in each medium, indicating that the heat of solution was exothermic in each case.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/43/4/287/37240807/j.2042-7158.1991.tb06688.x.pdf

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4. Cyclosporin: measurement of fraction unbound in plasma;Legg;J. Pharm. Pharmacol.,1987

5. The conformation of cyclosporin A in the crystal and solution;Loosli;Helv. Chim. Acta.,1985

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