Affiliation:
1. Pharmacy Department, Manchester University, Manchester M13 9PL, UK
Abstract
Abstract
The importance of excipient solubility in wet granulation has been shown using mixtures of lactose and boric acid containing third components of differing solubility characteristics. Sucrose dissolved in the binder solution and increased the amount of liquid available to form liquid bridges between other solid particles and therefore increased the number of solid bridges when the damp mass was dried. Thus, stronger, larger granules were formed. The results obtained with Sta-Rx 1500 and magnesium carbonate powders were also dependent upon the extent of solubility of these powders in the granulating solution.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference2 articles.
1. The granulation of ternary mixtures containing lactose and boric acid with different starches
2. 1st International Conference on Pharmaceutical Technology;Jehl;Paris Conference papers,1977
Cited by
50 articles.
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