Metabolism of Δ1-tetrahydrocannabinol by the isolated perfused dog lung. Comparison with in vitro liver metabolism-Reference-Cited by-同舟云学术

Metabolism of Δ1-tetrahydrocannabinol by the isolated perfused dog lung. Comparison with in vitro liver metabolism

Published:1975-11 Issue:11 Volume:27 Page:842-848
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Widman Marianne¹,Nordqvist Marianne¹,Dollery Colin T²,Briant Robin H²

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, BMC, Box 579, S-751 23 Uppsala, Sweden

2. M.R.C., Clinical Pharmacology Research Group, Royal Postgraduate Medical School, London W12, U.K.

Abstract

Abstract The metabolism of (—)-Δ1-tetrahydrocannabinol (Δ1-THC) has been studied in the isolated perfused dog lung. After intravascular administration of [3H]-Δ1-THC there was an overall biotransformation of 12%. Two major metabolites were isolated and identified as 3“-hydroxy-Δ1-THC and 4”-hydroxy-Δ1-THC. 7-Hydroxy-Δ1-THC was also present together with small amounts of 6α-hydroxy-Δ1-THC and 6β-hydroxy-Δ1-THC. An in vitro experiment using a dog liver microsomal preparation was also carried out and showed that the major metabolites were 6β-hydroxy-Δ1-THC and 6α-hydroxy-Δ1-THC. 7-Hydroxy-Δ1-THC and 1,2-epoxy-hexahydrocannabinol were also isolated together with small amounts of 3“-hydroxy-Δ1-THC and 4”-hydroxy-Δ1-THC. The side-chain hydroxylated compounds are hitherto undescribed metabolites of Δ1-THC.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/27/11/842/37613041/j.2042-7158.1975.tb10227.x.pdf

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