The Effect of Machine Speed on the Consolidation of Four Directly Compressible Tablet Diluents

Author:

Armstrong N Anthony1,Palfrey Lynn P1

Affiliation:

1. Welsh School of Pharmacy, University of Wales College of Cardiff, Cardiff, UK

Abstract

Abstract The reduction in porosity of a powder bed on compression was found to be a function of the velocity of the punch of the press. Substances which consolidated principally by fragmentation showed relatively little velocity dependence. However, the more important deformation was in a powder’s consolidation mechanism, the greater the dependence on punch velocity and hence tablet press speed.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference13 articles.

1. Time-dependent factors involved in powder compression and tablet manufacture;Armstrong;Int. J. Pharm.,1989

2. A proposed consolidation parameter for powders;Armstrong;J. Pharm. Pharmacol.,1983

3. Punch velocity during the compaction process;Armstrong;Ibid.,1987

4. The effect of machine speed on the compaction of some directly compressible tablet diluents;Armstrong;Ibid.,1985

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