Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

Author:

Yang Yang12,Jiang Shuai1,Dong Yushu34,Fan Chongxi5,Zhao Lei1,Yang Xiangmin1,Li Juan1,Di Shouyin5,Yue Liang1,Liang Guobiao3,Reiter Russel J.6,Qu Yan1

Affiliation:

1. Department of Neurosurgery; Xijing Hospital; The Fourth Military Medical University; Xi'an China

2. Department of Biomedical Engineering; The Fourth Military Medical University; Xi'an China

3. Department of Neurosurgery; General Hospital of Shenyang Military Area Command; Shenyang China

4. Department of Neurosurgery; The 463rd Hospital of PLA; Shenyang China

5. Department of Thoracic Surgery; Tangdu Hospital; The Fourth Military Medical University; Xi'an China

6. Department of Cellular and Structural Biology; UT Health Science Center; San Antonio TX USA

Funder

National Natural Science Foundation of China

The Excellent Doctoral Support Project of the Fourth Military Medical University

The New Century Talent Supporting Project by Chinese Education Ministry

Chinese Changjiang Scholars and Innovative Research Team in University

Publisher

Wiley

Subject

Endocrinology

Reference57 articles.

1. Therapeutic potential of melatonin in traumatic central nervous system injury;Samantaray;J Pineal Res,2009

2. Anticoagulant therapy for patients with ischaemic stroke;Hankey;Nat Rev Neurol,2012

3. Stroke in 2012: major advances in the treatment of stroke;Blanco;Nat Rev Neurol,2013

4. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma;Mattiasson;Nat Med,2003

5. Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage;Reiter;J Physiol Pharmacol,2007

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