Affiliation:
1. Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, National Stem Cell Translational Resource Center, School of Life Sciences and Technology Tongji University Shanghai China
Abstract
AbstractHippocampal neural stem cell (NSC) proliferation is known to decline with age, which is closely linked to learning and memory impairments. In the current study, we found that the expression level of miR‐181a‐5p was decreased in the hippocampal NSCs of aged mice and that exogenous overexpression of miR‐181a‐5p promoted NSC proliferation without affecting NSC differentiation into neurons and astrocytes. The mechanistic study revealed that phosphatase and tensin homolog (PTEN), a negative regulator of the AKT signaling pathway, was the target of miR‐181a‐5p and knockdown of PTEN could rescue the impairment of NSC proliferation caused by low miR‐181a‐5p levels. Moreover, overexpression of miR‐181a‐5p in the dentate gyrus enhanced the proliferation of NSCs and ameliorated learning and memory impairments in aged mice. Taken together, our findings indicated that miR‐181a‐5p played a functional role in NSC proliferation and aging‐related, hippocampus‐dependent learning and memory impairments.
Funder
National Natural Science Foundation of China
Cited by
4 articles.
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