Applications of single‐cell omics for chimeric antigen receptor T cell therapy

Author:

Ghaffari Sasan1,Saleh Mahshid2,Akbari Behnia3,Ramezani Faezeh45,Mirzaei Hamid Reza36ORCID

Affiliation:

1. Department of Immunology H. Lee Moffitt Cancer Center & Research Institute Tampa Florida USA

2. Wisconsin National Primate Research Center University of Wisconsin Graduate School Madison Wisconsin USA

3. Department of Medical Immunology, School of Medicine Tehran University of Medical Sciences Tehran Iran

4. Department of Medical Biotechnology, School of Paramedical Sciences Shiraz University of Medical Sciences Shiraz Iran

5. Department of Medical Laboratory Sciences, School of Paramedical Sciences Shiraz University of Medical Sciences Shiraz Iran

6. Molecular Imaging and Therapy Service, Department of Radiology Memorial Sloan Kettering Cancer Center New York New York USA

Abstract

AbstractChimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment modality. The breakthroughs in CAR T cell therapy were, in part, possible with the help of cell analysis methods, such as single‐cell analysis. Bulk analyses have provided invaluable information regarding the complex molecular dynamics of CAR T cells, but their results are an average of thousands of signals in CAR T or tumour cells. Since cancer is a heterogeneous disease where each minute detail of a subclone could change the outcome of the treatment, single‐cell analysis could prove to be a powerful instrument in deciphering the secrets of tumour microenvironment for cancer immunotherapy. With the recent studies in all aspects of adoptive cell therapy making use of single‐cell analysis, a comprehensive review of the recent preclinical and clinical findings in CAR T cell therapy was needed. Here, we categorized and summarized the key points of the studies in which single‐cell analysis provided insights into the genomics, epigenomics, transcriptomics and proteomics as well as their respective multi‐omics of CAR T cell therapy.

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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